Decode your DNA to unlock better Thyroid health

A significant percentage of people have genetic variations that make them more susceptible to developing autoimmune diseases. Additionally, there are specific genetic changes that can hinder the conversion of T4 to T3.

Here is your personalized analysis, which we hope will help you achieve better thyroid health.

The DNA test analysis shared here is for informational purposes only and do not represent a diagnosis. It is recommended that you consult with your doctor for any questions or concerns regarding your health. DNA test results are just a part of your overall health picture and should not be used to make any medical decisions.

SNPs associated with a higher risk of developing hypothyroidism:

rs7850258

Your genotype: AA

Using electronic medical record-linked DNA biobanks, a study with 1,317 cases and 5,053 controls of European American ancestry identified rs7850258 to have the strongest association with hypothyroidism. However, it's important to note that not everyone who carries the rs7850258 SNP will develop a thyroid disorder. Genetics is just one factor that can influence thyroid health, and other factors such as lifestyle choices and environmental exposures can also play a role.

People with the AA genotype  have slightly lower odds of developing primary hypothyroidism.

Your genotype: AG

Using electronic medical record-linked DNA biobanks, a study with 1,317 cases and 5,053 controls of European American ancestry identified rs7850258 to have the strongest association with hypothyroidism. However, it's important to note that not everyone who carries the rs7850258 SNP will develop a thyroid disorder. Genetics is just one factor that can influence thyroid health, and other factors such as lifestyle choices and environmental exposures can also play a role.

People with the AG genotype have "typical odds of developing primary hypothyroidism.

Your genotype: GG

Using electronic medical record-linked DNA biobanks, a study with 1,317 cases and 5,053 controls of European American ancestry identified rs7850258 to have the strongest association with hypothyroidism.  However, it's important to note that not everyone who carries the rs7850258 SNP will develop a thyroid disorder. Genetics is just one factor that can influence thyroid health, and other factors such as lifestyle choices and environmental exposures can also play a role.

People with the GG genotype  have slightly higher odds of developing primary hypothyroidism.

SNPs associated with a higher risk of developing an autoimmune condition such as Hashimoto's or Graves disease:

rs2071403

Your genotype: AA

Several studies have investigated the association between the rs2071403 SNP and Hashimoto's thyroiditis. The “G” allele is associated with increased risk of developing Hashimoto's or Graves disease. However, it's important to note that not everyone who carries the rs2071403 SNP will develop Hashimoto's thyroiditis. Genetics is just one factor that can influence thyroid health, and other factors such as environmental exposures, lifestyle choices, and immune system function can also play a role.

People with the AA genotype have no increased risk of autoimmune conditions

Your genotype: AG

Several studies have investigated the association between the rs2071403 SNP and Hashimoto's thyroiditis. The “G” allele is associated with increased risk of developing Hashimoto's or Graves disease. However, it's important to note that not everyone who carries the rs2071403 SNP will develop Hashimoto's thyroiditis. Genetics is just one factor that can influence thyroid health, and other factors such as environmental exposures, lifestyle choices, and immune system function can also play a role.

People with the AG genotype have no increased risk of autoimmune conditions

Your genotype: GG

Several studies have investigated the association between the rs2071403 SNP and Hashimoto's thyroiditis. The “G” allele is associated with increased risk of developing Hashimoto's or Graves disease. However, it's important to note that not everyone who carries the rs2071403 SNP will develop Hashimoto's thyroiditis. Genetics is just one factor that can influence thyroid health, and other factors such as environmental exposures, lifestyle choices, and immune system function can also play a role.

People with the GG genotype have an increased risk of autoimmune conditions like Hashimoto's or Graves.

the following SNP has been associated with thyroid-stimulating hormone (TSH) levels, which are a marker of thyroid function.

rs4704397

Your genotype: AA

This SNP has been associated with thyroid-stimulating hormone (TSH) levels, which are a marker of thyroid function. TSH is a hormone that is produced by the pituitary gland and regulates the production of thyroid hormones by the thyroid gland.
‍
Individuals with the AA genotype may have normal TSH levels, as this genotype is considered the reference or wild-type genotype. It means that both copies of the SNP carry the A allele, which is the more common allele in the general population.

Your genotype: AG

This SNP has been associated with thyroid-stimulating hormone (TSH) levels, which are a marker of thyroid function. TSH is a hormone that is produced by the pituitary gland and regulates the production of thyroid hormones by the thyroid gland.
‍
Individuals with the AG genotype may have slightly higher TSH levels compared to those with the AA genotype. This is because the G allele is associated with slightly higher TSH levels compared to the A allele.

Your genotype: GG

This SNP has been associated with thyroid-stimulating hormone (TSH) levels, which are a marker of thyroid function. TSH is a hormone that is produced by the pituitary gland and regulates the production of thyroid hormones by the thyroid gland.
‍
Individuals with the GG genotype may have significantly higher TSH levels compared to those with the AA genotype. This is because the GG genotype is associated with the highest TSH levels among the three genotypes.

SNPs associated with a higher risk of of thyroid hormone metabolism problems:

rs11206244

Your genotype: CC

This SNP is known to be associated with T3 hormone levels, and different genotypes of rs11206244 may have different effects on T3 production.

The CC genotype refers to having two copies of the C allele. Studies have shown that individuals with the CC genotype of rs11206244 may have lower levels of free triiodothyronine

This may suggest that the CC genotype is associated with reduced T3 hormone production or function

 Your genotype: CT

This SNP is known to be associated with T3 hormone levels, and different genotypes of rs11206244 may have different effects on T3 production.

The CT genotype refers to having one copy of the C allele and one copy of the T allele. The impact of this genotype on T3 hormone production is less clear and may vary depending on other genetic and environmental factors.

Some studies have suggested that individuals with the CT genotype may have intermediate levels of T3 compared to CC and TT genotypes, but more research is needed to confirm this.

Your genotype: TT

This SNP is known to be associated with T3 hormone levels, and different genotypes of rs11206244 may have different effects on T3 production.

The TT genotype refers to having two copies of the T allele. Studies have shown that individuals with the TT genotype of rs11206244 may have higher levels of free T3 compared to other genotypes, which may suggest that the TT genotype is associated with increased T3 hormone production or function.

rs225014

Your genotype: CC

The SNP rs225014 is a genetic variant that occurs in the human genome. It is located in the region of the genome associated with the production and regulation of thyroid hormone, specifically triiodothyronine (T3). The T3 hormone is an important thyroid hormone that plays a critical role in regulating metabolism, energy production, and growth.

Individuals with the CC genotype have two copies of the reference allele. This genotype is considered the wild-type or normal genotype. It is associated with normal or typical T3 hormone production.

Your genotype: CT

The SNP rs225014 is a genetic variant that occurs in the human genome. It is located in the region of the genome associated with the production and regulation of thyroid hormone, specifically triiodothyronine (T3). The T3 hormone is an important thyroid hormone that plays a critical role in regulating metabolism, energy production, and growth.

Individuals with the CT genotype have one copy of the reference allele and one copy of the variant allele. This genotype is heterozygous, meaning there is a mix of the reference and variant alleles. The impact of the CT genotype on T3 hormone production may vary, and it could potentially result in slightly altered T3 levels compared to the CC genotype. The exact effect of the CT genotype on T3 hormone production would depend on various factors, including other genetic and environmental factors

Your genotype: TT

The SNP rs225014 is a genetic variant that occurs in the human genome. It is located in the region of the genome associated with the production and regulation of thyroid hormone, specifically triiodothyronine (T3). The T3 hormone is an important thyroid hormone that plays a critical role in regulating metabolism, energy production, and growth.

Individuals with the TT genotype have two copies of the variant allele. This genotype is homozygous for the variant allele and may be associated with altered T3 hormone production. The T3 levels in individuals with the TT genotype may differ from those with the CC genotype, and there could be potential implications for thyroid function and metabolism.

rs2235544

Your genotype: AA

The SNP rs2235544, also known as the DIO2 gene polymorphism, is another genetic variant that has been associated with thyroid hormone production, specifically the conversion of thyroxine (T4) to triiodothyronine (T3) in the body.

AA genotype: less active DIO1 – decreased free T3, a larger decrease in T3 due to organochloride pesticides

Your genotype: AC

The SNP rs2235544, also known as the DIO2 gene polymorphism, is another genetic variant that has been associated with thyroid hormone production, specifically the conversion of thyroxine (T4) to triiodothyronine (T3) in the body.

AC genotype: intermediate (most common genotype in many populations)

Your genotype: CC

The SNP rs2235544, also known as the DIO2 gene polymorphism, is another genetic variant that has been associated with thyroid hormone production, specifically the conversion of thyroxine (T4) to triiodothyronine (T3) in the body.

CC genotype: more active DIO1enzyme – decreased free T4, increased fT3 (better ratio)

SNPs associated with a higher risk of goiters

rs12138950

Your genotype: AA

The SNP rs12138950, also known as the thyroid stimulating hormone receptor (TSHR) gene polymorphism, is a genetic variant that has been associated with an increased risk of goiter in some populations. Goiter is an enlargement of the thyroid gland, which can result in a visible swelling in the neck.

Only the carriers of the “C” allele had higher thyroid volume and higher rates of goiter. You don't have a higher risk of goiters.

Your genotype: AC

The SNP rs12138950, also known as the thyroid stimulating hormone receptor (TSHR) gene polymorphism, is a genetic variant that has been associated with an increased risk of goiter in some populations. Goiter is an enlargement of the thyroid gland, which can result in a visible swelling in the neck.

The carriers of the “C” allele had higher thyroid volume and higher rates of goiter

Your genotype: CC

The SNP rs12138950, also known as the thyroid stimulating hormone receptor (TSHR) gene polymorphism, is a genetic variant that has been associated with an increased risk of goiter in some populations. Goiter is an enlargement of the thyroid gland, which can result in a visible swelling in the neck.

The carriers of the “C” allele had higher thyroid volume and higher rates of goiter

It's important to note that the impact of a single genetic variant is likely to be complex and may be influenced by other genetic and environmental factors. Genetic variants often have subtle effects, and the full implications of a particular genotype may require further research and analysis. It's recommended to consult with a healthcare professional or a genetic counselor for a comprehensive evaluation of your specific genetic profile and its potential implications on thyroid hormone production or any other health-related concerns.