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Riboflavin may improve mood and prevent depression. One study finds that B2-deficient women exhibit a nonsignificant trend towards unipolar depression. Riboflavin is necessary for the development of folate-dependent pathways that may play a role in depression. Because riboflavin-derived coenzymes are sensitive to thyroid levels, supplementation can be a useful alternative to ensure the body has enough B2.
Riboflavin can help reduce the proinflammatory cytokines and oxidative stress that aggravate autoimmune conditions. While B2 deficiency cannot be said to cause autoimmune conditions, it is possible that such a deficiency may prevent someone with Hashimoto’s from calming the root cause of their thyroid autoimmunity.
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