Estriol Face Cream
A prescription topical estriol treatment designed to support smoother, more hydrated-looking skin and address visible changes in texture and fine lines associated with hormonal shifts.
Estriol face cream uses
- Designed to support hydration, smoother-looking texture, and the appearance of fine lines.
- A prescription approach for skin changes associated with hormonal shifts.
- Personalized and prescribed after a clinician reviews your history.
Good to know
- Volume. 30 mL.
- Formulation. Compounded estriol 0.3% with vitamin A palmitate, aloe vera, and sodium hyaluronate; prescription-only, prescribed off-label.
- Estrogen-class precaution. Estriol is an estrogen; estrogen products carry class risks (including blood clots, stroke, and breast/endometrial cancer). Your clinician screens your history first.
- Not in pregnancy. Not for use in pregnancy, breastfeeding, or while trying to conceive.
- Use daily sunscreen. Vitamin A palmitate can increase sun sensitivity; wash your hands after applying so it doesn’t transfer to others.
- Medication guide. Read the medication guide (PDF).
Prescription skincare for hormonal changes
Care for your skin’s changing needs.
When hormonal changes show up in your skin
Skin can become drier, feel different, and show changes in texture and fine lines as hormones shift. Estriol Face Cream offers a prescription approach designed specifically for these changes.
- Hydration. Supports more hydrated-looking skin.
- Texture. Designed to support smoother-looking skin and texture.
- Visible signs of aging. Intended to address changes such as dryness, texture, and the appearance of fine lines.
- Personalized prescription care. A clinician reviews your health history and determines whether topical estriol is appropriate for you.
Skincare, with a hormonal lens
Moisturizers and traditional skincare can address the surface of dry or changing skin. Estriol Face Cream is a prescription option for patients whose skin concerns may be connected to hormonal changes, and who want to explore a clinician-guided approach.
More than estriol alone
A compounded prescription formula that combines topical estriol with complementary skincare ingredients selected for hydration, texture, and skin feel.
- Estriol 0.3%. A form of estrogen used topically and off-label in this prescription formula.
- Vitamin A palmitate. A vitamin A derivative included to complement the formula’s skincare approach.
- Aloe vera and sodium hyaluronate. Included to support hydration and a comfortable skin feel.
Compounded to order by a licensed pharmacy in its skincare base; your full ingredient list is on your medication guide.
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Get treated
Designed for consistent care, not an overnight fix
- Getting started. Your skin may need time to adjust — mild dryness, warmth, or brief stinging can occur.
- With consistent use. Changes in hydration, texture, and the appearance of fine lines can develop gradually.
- Over time. Continue using it as prescribed, and check in with your clinician if your skin needs change.
Read your medication guide
Review the full medication guide for additional product and safety information.
Frequently asked questions
How does estriol face cream work?
Estriol is a form of estrogen. When used topically on the skin, it may help support hydration, skin texture, and visible signs of aging in some patients. Response varies, and benefits are not guaranteed.
Is estriol face cream FDA-approved for anti-aging or skin rejuvenation?
No. Estriol Face Cream is a compounded prescription medication used off-label. Your clinician will review your health history and determine whether it is appropriate for you.
Can I use it with my other skincare products?
Possibly. Your clinician can help you decide how to use Estriol Face Cream with other products such as moisturizers, sunscreen, retinoids, acids, or vitamin C. Avoid combining with irritating products unless directed.
Can I use it around my eyes?
This product is intended for facial use as directed, but you should avoid direct contact with the eyes. If you are looking for an under-eye product, your clinician may recommend a separate eye-specific formulation.
Can I use it if I am on hormone therapy?
Tell your clinician about any hormone therapy you are using, including estrogen, progesterone, testosterone, DHEA, or vaginal estrogen, so they can review whether this treatment is appropriate.
What should I do if my skin gets irritated?
Mild irritation can happen. Stop using the medication and contact your clinician if irritation is persistent, worsening, or severe.
Who should not use it?
It isn't prescribed during pregnancy, breastfeeding, or while trying to conceive. Because estriol is an estrogen, it also isn't appropriate if you have breast cancer or another estrogen-sensitive cancer, or take tamoxifen or an aromatase inhibitor, and your clinician will weigh any history of blood clots or stroke. Tell your clinician about any systemic estrogen or hormone-replacement therapy and your full skincare routine. Your clinician reviews your health history to decide whether it's appropriate for you.
How does the process work?
Complete an online health questionnaire about your medical history, current medications, and treatment goals. A licensed clinician reviews your information and determines whether treatment is appropriate. If prescribed, you’ll receive treatment instructions and can complete checkout for medication delivery.
Do I need a video appointment?
Eligible patients can receive care through an online questionnaire and messaging, without scheduling a video call. Your clinician may recommend a live or in-person visit if additional evaluation is needed.
Which states are eligible for online questionnaire-based visits?
Our asynchronous visits are currently available in:
Arizona, California, Colorado, Florida, Illinois, Iowa, Maryland, Massachusetts, Michigan, Minnesota, Montana, Nebraska, Nevada, New Hampshire, New Jersey, New Mexico, New York, North Carolina, North Dakota, Ohio, Oklahoma, Oregon, Pennsylvania, South Carolina, South Dakota, Tennessee, Texas, Utah, Virginia, Washington, Wisconsin, and Wyoming.
Availability is confirmed during intake. Eligibility also depends on your medical history and the medication requested. If your state isn’t listed, asynchronous care is not currently available there.
Is a prescription guaranteed?
No. A prescription is issued only when a licensed clinician determines that treatment is appropriate for you. Completing the questionnaire does not guarantee a prescription.
What is a compounded medication?
A compounded medication is prepared by a pharmacy according to a prescription to meet an individual patient’s needs. Compounded medications are not FDA-approved, and the FDA does not review their safety, effectiveness, or quality before they are marketed.
How will I receive my medication?
After your prescription is approved and payment is completed, our licensed partner pharmacy processes your order and ships it to the address confirmed at checkout. You’ll receive tracking information by text or email once it ships. Preparation and delivery times can vary.
Can I use insurance for my medication?
Medication costs and prescription coordination fees are self-pay and are not billed to insurance. You’ll see a breakdown of these costs before confirming payment.
How do refills work?
Refills require a valid prescription and remaining authorized refills. Depending on your medication, you may need to complete a health check-in before a refill can proceed. When your prescription expires or you run out of authorized refills, a new clinical evaluation may be required.
Can I change or cancel automatic refills?
Yes. Use the “Manage refills” link in your refill notification or patient portal to manage upcoming refills, update shipping or payment details, or cancel automatic refills. Make changes before the scheduled charge date.
Who can I contact with questions?
Contact your Paloma care team with questions about your treatment or prescription. For help with orders, shipping, or refills, email contact@palomahealth.com.
Important safety information
Estriol Face Cream is compounded and used off-label. It is not FDA-approved for facial aging, wrinkles, skin thinning, dryness, collagen support, or cosmetic use.
Do not use if you are pregnant, trying to become pregnant, or breastfeeding unless specifically approved by your clinician. Tell your clinician if you have a history of breast cancer, uterine cancer, ovarian cancer, unexplained vaginal bleeding, blood clots, stroke, liver disease, or if you are using other hormone therapies.
Apply only as directed. Avoid contact with the eyes, mouth, and mucous membranes. Do not apply to broken, irritated, or infected skin. Wash hands after use. Stop use and contact your clinician if you develop significant irritation, rash, swelling, breast tenderness, vaginal bleeding, or any concerning symptoms.
Active ingredients
- Estriol 0.3%
- Vitamin A Palmitate
- Aloe Vera
- Sodium Hyaluronate
Inactive ingredients
- Biopeptide Biocosmetic cream base
- Skin irritation, redness, or sensitivity
- Dryness or peeling
- Temporary stinging or burning at the application site
- Breakouts or clogged pores
- Hormone-related side effects, such as breast tenderness or spotting, may occur in some patients
Store at room temperature, away from heat, moisture, and direct sunlight. Keep the container tightly closed when not in use.
Estriol Face Cream is for external use only. Avoid contact with the eyes, mouth, and mucous membranes. Do not use during pregnancy, while trying to become pregnant, or while breastfeeding unless specifically approved by your clinician. Do not use if you have a history of estrogen-sensitive cancer, unexplained vaginal bleeding, blood clots, stroke, or liver disease unless your clinician determines it is appropriate. Keep out of reach of children and pets.
Read your medication guide
Review the full medication guide for additional product and safety information.
Compounded medications
More options for your care.
Explore additional options for hair, skin, sexual wellness, and more—alongside the thyroid, HRT, and weight loss care we provide through live visits.
Compounded drug products are not approved or evaluated for safety, effectiveness, or quality by the FDA. Rx Required.
