Natural Desiccated Thyroid Drug Adthyza Discontinued

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In the past several years, a natural desiccated thyroid (NDT) drug, Adthyza, became available, but has, as of late November 2025, been discontinued. Adthyza was a brand-name NDT drug manufactured by Azurity Pharmaceuticals, Inc., which was formerly known as CutisPharma, Inc., the parent company of Silvergate Pharmaceuticals, Inc.

Adthyza was made from porcine (pig) thyroid glands and used as a thyroid hormone replacement medication to treat low thyroid hormone levels (hypothyroidism). Like other NDT drugs, Adthyza included natural forms of thyroxine (T4) and triiodothyronine (T3). All NDT drugs are federally regulated – but not approved – by the Food and Drug Administration (FDA).

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According to the manufacturer, Adthyza was free of lactose, corn, dyes, and latex. The inactive ingredients in Adthyza Thyroid tablets were:

• Calcium stearate
• Colloidal silicon dioxide
• Dextrose
• Mannitol
• Microcrystalline cellulose
• Sodium starch glycolate

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Adthyza was available in 5 strengths:

• ¼ grain / 16.25 mg: which has 9.5 mcg of T4 and 2.25 mcg of T3
• ½ grain / 32.5 mg: which has 19 mcg of T4 and 4.5 mcg of T3
• 1 grain / 65 mg: which has 38 mcg of T4 and 9 mcg of T3
• 1 ½ grains / 97.5 mg: which has 57 mcg of T4 and 13.5 mcg of T3
• 2 grains / 130 mg: which has 76 mcg of T4 and 18 mcg of T3

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When this article was originally published, according to GoodRx, the cash price of Adthyza at various pharmacies ranged from $29 to $38 for a 30-day supply of 1 grain (65 mg) tablets and $84 to $90 for a 90-day supply of 1 grain (65 mg) tablets.

Adthyza also offered an Azurity Solutions - Patient Direct “affordable access program” called Adthyza Cares, which offered similar prices for mail-order purchases by patients with hypothyroidism who don’t have health insurance. According to the Adthyza Cares program, no insurance was required to get guaranteed cash pricing and home delivery to all 50 U.S. states.

For cash-paying patients, costs were estimated at $35 for a 30-day supply and $90 for a 90-day supply.

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Adthyza appeared similar to its competitors, Armour Thyroid (manufactured by AbbVie) and NP Thyroid (manufactured by Acella.) The main differences were in their inactive ingredients, pricing, and dosage sizes.

Compared to Adthyza’s six inactive ingredients, Armour Thyroid has only five, including:

• Calcium stearate
• Dextrose
• Microcrystalline cellulose
• Sodium starch glycolate
• Opadry white

NP Thyroid has only three inactive ingredients:

• calcium stearate
• dextrose
• mineral oil

As far as price, Adthyza was priced more closely to NP Thyroid, which according to GoodRx, runs from $24 to $40 a month for a one-month supply of 1 grain/60 mg and $60 to $101 for a three-month supply.

A one-month supply of Armour (1 grain/60 mg) runs $35 - $43, and $95 to $116 for a three-month supply.

Similar to Adthyza, Armour has dosage sizes of ¼ grain/15 mg, ½ grain/30 mg, 1 grain/60 mg, 1 ½ grain/90 mg, 2 grains/120 mg. Armour has one additional dosage size, 3 grains/180 mg.

NP Thyroid has the same five dosages as Adthyza –  ¼ grain/15mg, ½ grain/30mg, 1 grain/60mg, 1 ½ grain/90mg, and 2 grains/120mg.

One interesting difference: Adthyza had a valuable and novel tool on their website that you won’t find on their competitor’s websites. On the “Get to Know Adthyza” page, under “Confidence and Quality: Look Up Your Lot,” you could enter the lot number from your prescription to see the testing information for your lot’s quality, consistency, and potency.

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The choice of taking levothyroxine versus natural desiccated thyroid for your thyroid hormone replacement is best made in partnership with a knowledgeable healthcare provider who can provide sound medical advice for your hypothyroidism treatment.

Paloma’s team of top thyroid providers can work with you to map out a personalized plan for optimal wellness and thyroid health. Get started by scheduling an appointment with a Paloma provider today.

Also, remember that if you are working with your healthcare provider to change your treatment of hypothyroidism – and optimize that treatment – you should have your thyroid levels checked regularly. Typically, a thyroid panel is done before you change thyroid hormone therapy or medication dose and periodically after that to assess your thyroid health and function over time. You may find this testing process more accessible by using a convenient home test kit from Paloma Health, which evaluates thyroid stimulating hormone (TSH), Free Thyroxine (Free T4), Free Triiodothyronine (Free T3), and Thyroid Peroxidase Antibodies (TPOAb).

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Is Adthyza still available?

No. As of late November 2025, Adthyza has been discontinued, according to the drug's website. It's not clear why the manufacturer, Azurity, discontinued it, or whether this is connected to the 2025 FDA regulatory actions affecting natural desiccated thyroid drugs.

What was Adthyza made from?

Adthyza was a natural desiccated thyroid (NDT) drug made from porcine (pig) thyroid glands. It was used as a thyroid hormone replacement medication to treat low thyroid hormone levels (hypothyroidism), and like other NDT drugs, it contained natural forms of thyroxine (T4) and triiodothyronine (T3).

What ingredients were in Adthyza?

According to the manufacturer, Adthyza was free of lactose, corn, dyes, and latex. Its inactive ingredients were calcium stearate, colloidal silicon dioxide, dextrose, mannitol, microcrystalline cellulose, and sodium starch glycolate.

What dosage strengths did Adthyza come in?

Adthyza was available in 5 strengths: 1/4 grain (16.25 mg), 1/2 grain (32.5 mg), 1 grain (65 mg), 1 1/2 grains (97.5 mg), and 2 grains (130 mg). Each strength provided a specific combination of T4 and T3.

How much did Adthyza cost?

When this article was originally published, the cash price of Adthyza ranged from $29 to $38 for a 30-day supply of 1 grain (65 mg) tablets and $84 to $90 for a 90-day supply, according to GoodRx. Adthyza also had a mail-order "affordable access program" called Adthyza Cares for patients without health insurance, with cash-paying costs estimated at $35 for a 30-day supply and $90 for a 90-day supply.

How did Adthyza compare to Armour Thyroid and NP Thyroid?

Adthyza was similar to both competitors, with the main differences being in inactive ingredients, pricing, and dosage sizes. Adthyza had six inactive ingredients, compared to five for Armour Thyroid and three for NP Thyroid. Adthyza's pricing was closer to NP Thyroid's, and it shared the same five dosage sizes as NP Thyroid, while Armour Thyroid offered one additional, larger dosage size. Adthyza also had a unique "Look Up Your Lot" tool on its website where patients could check testing information for their specific lot's quality, consistency, and potency.