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How To Get Off Thyroid Medication

Learn about when it’s safe to stop your thyroid medication and how to do it.
How To Get Off Thyroid Medication
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If you live with hypothyroidism, you probably take daily thyroid medication. These thyroid hormone medications include levothyroxine drugs like Synthroid, T3 drugs like Cytomel, or natural desiccated thyroid medications like Armour Thyroid. Thyroid hormone replacement drugs supplement your naturally produced thyroid hormone when your thyroid can’t make enough on its own. Because of this, thyroid medication is usually taken for life. 

You may have heard stories, however, of how some people have been able to stop taking thyroid hormone replacement medication safely. Is this something that you can – or should do? If so, what are the steps in safely stopping your thyroid medication? 

Before we explore these questions, let’s be clear: it’s a terrible idea to stop taking your prescribed medication for hypothyroidism unless directed by your doctor. Before considering this option, here’s what you need to know about the process. 

Are you a candidate to stop taking thyroid hormone replacement medication?

You may be a candidate to stop taking your thyroid medication if you have a form of underactive thyroid known as subclinical hypothyroidism. Subclinical hypothyroidism (SCH) is defined as slightly increased TSH levels with normal Free T4 levels. You may or may not have hypothyroidism symptoms, and SCH is considered a mild form of hypothyroidism.

A 2021 study showed that about 40% of those initially diagnosed with SCH remained euthyroid – normal thyroid function – after stopping their thyroid medication. Their thyroid hormone levels remained within the normal range. 

If you were prescribed medication to treat subclinical hypothyroidism or a slightly sluggish thyroid, you should know that there are differing opinions on whether even to treat SCH in the first place. Some patients with SCH take thyroid medication but appear to gain no benefit from taking it. Others find that low-dose thyroid hormone replacement helps relieve mild symptoms of subclinical hypothyroidism. Once on thyroid medication for SCH, the only way to know if you can safely stop taking it is through trial and error.

SCH differs from overt hypothyroidism, which involves an elevated thyroid stimulating hormone (TSH) level at diagnosis, with a low free thyroxine (Free T4) level. Patients with overt hypothyroidism or who developed elevated TSH and low Free T4 after stopping medication in the past are usually not good candidates to stop taking thyroid medication. According to studies of patients with overt hypothyroidism, only 12% remained euthyroid and asymptomatic after stopping thyroid medication. 

Also, note that some thyroid patients will never be able to stop getting treatment for hypothyroidism and shouldn’t try. These include people who are hypothyroid due to surgical removal or total ablation with radioactive iodine (RAI) of the thyroid gland – or longstanding Hashimoto’s that has atrophied the thyroid gland. These patients either have no thyroid gland or a gland incapable of producing essential thyroid hormones they need to survive. 

Getting off your thyroid medication

If you are subclinically hypothyroid and want to stop your medication, your first step is to talk with your thyroid care provider. Together, you will develop a plan to reduce your thyroid medication dose over time safely.

Under the supervision of your thyroid doctor, you will slowly cut back on your dose. As you cut back, symptoms of hypothyroidism – such as fatigue, cold intolerance, brain fog, or changes in your mood – may start to occur. This is normal, as the body adjusts to making thyroid hormone again. If the symptoms become more debilitating, your doctor may reduce your dosage more slowly, giving your body more time to adjust. Your thyroid specialist will test your thyroid function frequently during this process. 

If your symptoms don’t resolve or worsen noticeably, this is a sign that you may be unable to stop your medication. Be sure to communicate with your doctor about your symptoms during this process.  

Other approaches

If you are borderline or subclinically hypothyroid, several other approaches may also help you normalize thyroid levels, resolve unrelieved thyroid symptoms, and potentially allow you to stop taking thyroid medication. These include:

Selenium supplementation: This mineral can help reduce thyroid antibodies and aid in T4 to T3 conversion. These changes may be enough to allow patients with mild hypothyroidism to safely stop taking thyroid medication without a return of symptoms. 

Iodine supplementation: In some thyroid patients, iodine deficiency can cause SCH. In those patients, testing for and supplementation with iodine may restore thyroid levels to normal and allow patients to safely stop taking medication.

Low-dose naltrexone (LDN): Naltrexone – an anti-addiction medication – is prescribed off-label at low doses for autoimmune diseases. In some cases, treatment with LDN can reduce antibodies and improve thyroid levels to the extent that a patient can safely stop taking medication.  

Autoimmune Protocol (AIP) diet: For some patients, carefully following the AIP diet may relieve symptoms and reduce antibodies, allowing a subclinically hypothyroid patient to stop taking thyroid medication. 

Gluten-free diet: Some thyroid patients with celiac disease or gluten sensitivity have had a reduction in thyroid antibodies and normalization of thyroid levels after following a gluten-free diet. This may allow for stopping thyroid medication in some cases.  

Lifestyle: Don’t forget that sleep, hydration, maintaining a healthy gut, managing stress, and being part of a supportive community are also important ways to sustain your thyroid-healthy lifestyle!  

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A note from Paloma Health

You should never attempt to stop taking your thyroid medication on your own. Suddenly stopping your thyroid medication can lead to worsening hypothyroidism, with adverse reactions and hypothyroid symptoms that include rapid weight gain, fatigue, and depression, as well as heart problems. In rare cases, failure to treat a thyroid condition can result in a life-threatening coma.

We recommend you work with one of Paloma’s knowledgeable thyroid doctors to map out your personalized plan for optimal wellness and thyroid health. Schedule an appointment with one today.

Also, remember that if you are working with your healthcare provider to get off your thyroid medication, you should have your thyroid levels checked. Typically, a thyroid panel is done before you start tapering down your medication dose and periodically after that to assess your thyroid health and unmedicated thyroid function over time. You may find this testing process easier by using a comprehensive home test kit from Paloma Health, which evaluates TSH, Free T4, Free T3, and TPO antibodies as part of a complete thyroid panel.

Finally, if you want to try the AIP diet for your thyroid health, download the free Paloma Health App. The app includes a 12-week Hashimoto’s Protocol, featuring the AIP diet. With guidelines, tips, recipes, and other information, you can help support healthy thyroid function with diet and lifestyle changes.


Gavrila A. Subclinical thyroid disease increases the incidence of heart failure in older persons. Clinical Thyroidology for the Public. 2012;5(6).

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O’Kane SM, Mulhern MS, Pourshahidi LK, Strain JJ, Yeates AJ. Micronutrients, iodine status and concentrations of thyroid hormones: a systematic review. Nutr Rev. 2018;76(6):418-431. doi:10.1093/nutrit/nuy008

Mitra S, Paul S, Roy S, Sutradhar H, Bin Emran T, Nainu F, et al. Exploring the Immune-Boosting Functions of Vitamins and Minerals as Nutritional Food Bioactive Compounds: A Comprehensive Review. Molecules. 2022;27(2):555. doi:10.3390/molecules27020555

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Zielinski MR, Systrom DM, Rose NR. Fatigue, Sleep, and Autoimmune and Related Disorders. Front Immunol. 2019;10. doi :

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Emilie White, PharmD

Clinical Pharmacist and Medical Blogger

Emilie White, PharmD is a clinical pharmacist with over a decade of providing direct patient care to those hospitalized. She received her Doctor of Pharmacy degree from Massachusetts College of Pharmacy and Health Sciences. After graduation, Emilie completed a postgraduate pharmacy residency at Bon Secours Memorial Regional Medical Center in Virginia. Her background includes caring for critical care, internal medicine, and surgical patients.

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